Tropical Journal of Pharmaceutical Research

Original Research Article | OPEN ACCESS

Clinical efficacy of a combination of propofol and etomidate in pediatric anesthesia, and its effect on vital indices in patients

Li Li, Yangzi Ding, Junli Yao, Qiongge Sun, Fengchao Zhang

Department of Anesthesiology, Xuzhou Children's Hospital, Xuzhou Medical University, Xuzhou 221002, PR China;

For correspondence:- Fengchao Zhang Email: zhangfengchao96@126.com Tel:+8615895229712

Accepted: 1 September 2021 Published: 30 September 2021

Citation: Li L, Ding Y, Yao J, Sun Q, Zhang F. Clinical efficacy of a combination of propofol and etomidate in pediatric anesthesia, and its effect on vital indices in patients. Trop J Pharm Res 2021; 20(9):1975-1981 doi: 10.4314/tjpr.v20i9.26

© 2021 The authors.
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Abstract

Purpose: To study the clinical effectiveness of a combination of propofol and etomidate as pediatric anesthesia, and its influence on some vital factors in the patients.

Methods: A total of 104 children who underwent appendectomy, hepatobiliary surgery and excision of bone tumor in Xuzhou Children's Hospital, Xuzhou Medical University, Xuzhou, China from June 2018 to June 2020, were selected for this retrospective study. The patients were divided into groups A, B and C. In group A, 40 patients received the combination of propofol and etomidate, 32 patients received propofol only, while group C comprised 32 patients who received etomidate only. Vital indices such as anesthesia induction time, wake-up time after surgery, anesthetic effect, and adverse reactions were determined.

Results: In group A, the mean arterial pressure (MAP) and heart rate (HR) were improved; anesthesia induction time and wake-up time after surgery were shorter, and anesthetic effect was more obvious in children with grades I and II. However, there was no grade III anesthetic effect, although there was a lower incidence of adverse reactions in this group.

Conclusion: The use of a combination of propofol and etomidate results in higher clinical efficacy of pediatric anesthesia than either propofol or etomidate alone. Furthermore, the combination produces better quality of vital indices in the patients.

Keywords: Propofol, Etomidate, Pediatric anesthesia, Mean arterial pressure, Heart rate, Anesthetic effect